Cross direction: Separation of chiral drug molecular , artificial bionic synaptic devices
Cross direction: Separation of chiral drug molecular , artificial bionic synaptic devices
Chirality is a key feature of many drugs, and the ability to selectively detect and manipulate chiral molecules is of great importance in drug development. HandyMolecule is a molecular screening and manipulation platform that uses artificial biosynthetic neural synapses to selectively detect and manipulate chiral molecules. It utilizes a unique combination of nanostructured electrodes and microfluidics to rapidly detect and manipulate chiral molecules, enabling accurate and efficient drug screening and development. The platform is capable of detecting and manipulating molecules in a wide range of sizes, shapes, and conformations, and can be used to identify and optimize new drugs. It also has the potential to be used in the development of novel drug delivery systems, such as targeted drug delivery, and can be used to investigate the effects of chirality on drug efficacy.
Figure1：Schematic diagram of molecular selection of chiral drugs (Banerjee-Ghosh et al., Science 360, 1331–1334 (2018))
The charge polarization of chiral molecules is accompanied by spin polarization. The specific spin orientation at each pole depends on the chirality of the molecule, and spin polarization is caused by the dynamic process of molecular redistribution of electrons in the chiral potential.
1. The two spins are antiparallel (low-spin configuration), the interaction between the substrate and the molecule should be stable.
2. If two spins are parallel (high spin configuration), they are unstable.
When the magnetic dipole points upward, one enantiomer preferentially adsorbs, while the other enantiomer adsorbs faster in the opposite direction of magnetization. This interaction is related to the magnetic exchange interaction between spin-polarized molecules and spin-polarized substrates, which opens up a new way for chiral separation.
Artificial neuromorphic synapse device is a device that mimics the function of a biological synapse. It is based on the principles of artificial intelligence and machine learning, and is able to process and transmit information in a similar way to the human brain. The device consists of an array of transistors, capacitors and resistors that can be programmed to simulate the behavior of a biological synapse. It can be used to create artificial neural networks, which are used in artificial intelligence applications such as image recognition and natural language processing. The device can also be used to create neuromorphic computing systems, which are capable of learning and adapting to changes in their environment.
Figure2：Schematic of a multi-level photo-neuronal synaptic device based on MoS2 phototransistor under gate regulation under different illumination (Kim et al, ACS NANO, 10294-10300, 2019)